Table 1.

Specific mutations in neuroblastoma (NB) cell lines

Cell line	Ref.	P53	ALK	MNA	1pLOH	MK-2206 (IC50 μM)
SKN-AS	12	Δexon9	Wt	−	+	16.5
SKN-FI	26	M246R	S1136S	−	−	8.7
SKN-DZ	6	R110L	Wt	+	−	8.1
SKN-BE2	12	C135F	Wt	+	+	3.6
SY5Y	6	Wt	F1174L	−	−	1.7
LAN5	27	Wt	R1275Q	+	+	1.3
SMS-KCNR	12	Wt	R1275Q	+	+	1.1
NGP	12	Wt	Wt	+	−	0.6

P53 = a tumor suppressor gene

ALK = anaplastic lymphoma kinase; MNA = MYCN gene amplification

MNA = MYCN gene amplification

1pLOH = loss of heterozygosity at chromosome 1p

Wt = wild type.