Neutrophils decrease significantly in KC-Tie2 mice after IL-12/23, IL- 17A, and IL-17RA blockade. (a) CD11b+Ly6Chigh monocytes, (b) CD11b+Ly6Clow monocytes, (c) CD11b+Ly6G+ neutrophils, and (d) CD4+ T cells from spleens of KC-Tie2 mice treated with isotype IgG (n = 5, mouse; n = 4, mouse rat), anti-IL- 12p40 (n = 5), anti-IL-23p19 (n = 5), anti-IL-17A (n = 5), or anti-IL-17RA (n = 5). Each symbol represents an individual mouse. Solid straight lines indicate the mean for each group. Data were analyzed using a Fishers least significant difference test. *P < 0.05 versus isotype IgG.