Table 6.
Cox proportional hazards model for CLAD using BAL CXCL9 concentrations during respiratory infection
| Model 1 ƚ | Model 2 ƚ | Model 3 ƚ | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | HR | 95% CI | |||||||||
| ALI | 1.4 | 0.97 | - | 2.0 | 1.4 | 1.01 | - | 2.0 | 1.4 | 0.99 | - | 2.0 | ||
| OP | 1.3 | 0.95 | - | 1.8 | 1.3 | 0.9 | - | 1.8 | 1.4 | 1.01 | - | 1.9 | ||
| AR ≥ A1 | 1.2 | 0.9 | - | 1.7 | 1.2 | 0.9 | - | 1.6 | 1.2 | 0.92 | - | 1.6 | ||
| Infection + CXCL9 > 25th ƚƚ | 1.8 | 1.1 | - | 2.8 | ||||||||||
| Infection + CXCL9 > 50th ƚƚ | 2.4 | 1.4 | - | 4.0 | ||||||||||
| Infection + CXCL9 > 75th ƚƚ | 4.4 | 2.4 | - | 8.0 | ||||||||||
Definition of abbreviations: CLAD = chronic lung allograft dysfunction, BAL = bronchoalveolar lavage fluid, % = percentile, HR = hazard ratio, CI = confidence interval, ALI = acute lung injury, OP = organizing pneumonia, LB = lymphocytic bronchiolitis, AR = acute rejection, A1 = grade A1,
ƚ
Multivariable model adjusted for variables listed.
ƚƚ
CXCL9 > 25th: 363.64 pg/ml, CXCL9 > 50th: 2729.56 pg/ml, CXCL9 > 75th: 8584.00 pg/ml. P-values: * < 0.05, ** < 0.01, *** < 0.001.