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. 2019 Aug 7;10:1877. doi: 10.3389/fimmu.2019.01877

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Copyright © 2019 Kildey, Francis, Hultin, Harfield, Giuliani, Law, Wang, See, John, Ungerer, Wilkinson, Kassianos and Healy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Significantly increased CD56^bright NK cells in TCMR. (A,B) Absolute numbers of total (A) CD56^bright NK cells and (B) CD56^dim NK cells in kidney transplant biopsy tissue with histopathological diagnosis of no rejection (n = 7), borderline cellular rejection (n = 10) and T cell-mediated rejection (TCMR; grades I–II; n = 7). Values for individual donors are presented; donors with DSA are identified using open symbols; bars represent means. (C,D) Surface expression of CD69 on (C) CD56^bright NK cells and (D) CD56^dim NK cells in kidney transplant biopsy tissue with histopathological diagnosis of no rejection (n = 7) and borderline or T cell-mediated rejection (n = 8). Median fluorescence intensity (median FI) values for individual donors are presented; bars represent means, with mean values presented in parentheses. **P < 0.01, Kruskal-Wallis test with Dunn's post-test.