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. 2019 Aug 7;10:1877. doi: 10.3389/fimmu.2019.01877

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Copyright © 2019 Kildey, Francis, Hultin, Harfield, Giuliani, Law, Wang, See, John, Ungerer, Wilkinson, Kassianos and Healy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human CD56^dim natural killer (NK) cells in AMR biopsies display an activated phenotype. (A,B) Surface expression of CD69 on CD56^bright NK cells (A) and CD56^dim NK cells (B) in biopsy specimens without (no rejection; n = 7) and with AMR (n = 4). (C,D) Surface expression of (C) CD16 and (D) HLA-DR on CD56^dim NK cells in biopsy specimens without (no rejection; n = 14) and with AMR (n = 10). Median fluorescence intensity (median FI) values for individual donors are shown; bars represent means, with mean values presented in parentheses. *P < 0.05, Mann-Whitney test.