Table 1.
Participant characteristics | Analytic samplea | Early PA slopeb | Late PA slopeb | Early PF slopeb | Late PF slopeb |
---|---|---|---|---|---|
Cycle 1 | n = 1,404 | (Cycles 1–5) | (Cycles 5–9) | (Cycles 1–5) | (Cycles 5–9) |
Age | 76.96 (7.2) | 0.01 | 0.05* | 0.25** | −0.07* |
Sex, female | 876 (62.4%) | −0.64 | −1.41 | −0.27 | 0.23 |
Race, white | 1337 (95.2%) | −1.52 | 0.52 | −0.12 | 1.25 |
Education, >HS | 609 (43.38%) | 0.21 | 0.31 | 9.46** | 1.72 |
MMSE score | 27.84 (1.99) | 0.05 | 0.01 | 0.01 | 0.02 |
CDR score, MCI (score = 0.5)# | 338 (24.1%) | 0.24 | 0.08 | 16.48** | 3.44* |
Painful gait, present | 158 (11.3%) | −0.80 | 0.20 | 0.13 | 0.47 |
≥1 Alcohol drinks/week | 324 (23.1%) | −0.30 | 0.26 | 1.26 | 0.34 |
Ever smoker | 734 (52.3%) | −0.64 | −0.37 | 2.04* | 0.32 |
BMI | 28.06 (5.40) | 0.05 | 0.06* | 0.02 | 0.05 |
Stroke/TIA, present | 153 (10.9%) | 0.52 | −0.66 | −2.71* | 0.75 |
Myocardial infarction, present | 192 (13.7%) | 0.52 | 0.65 | −1.88 | −0.61 |
Hypertension, present | 900 (64.1%) | 0.53 | 0.52 | −2.06* | −1.31 |
Diabetes, present | 289 (20.6%) | −0.30 | −0.97 | −1.38 | −0.59 |
Heart failure, present | 99 (7.1%) | 2.28* | −1.16 | −1.83 | 0.04 |
TUG time, sec | 12.75 (4.06) | −0.01 | 0.04 | −0.02 | −0.23** |
PA, min/week | 66.45 (115.12) | −0.56** | −0.33** | −0.04 | −0.04 |
Cycle 9 | |||||
TUG time, sec | 14.40 (4.31) | 0.03 | −0.02 | 0.24** | 0.67** |
PA, min/week | 33.61 (73.43) | 0.12* | 0.26** | −0.07* | −0.14** |
MMSE score | 28.07 (3.86) | 0.06 | 0.06 | −0.04 | −0.04 |
Worsening CDR score, present | 120 (8.6%) | 1.79 | 1.10 | −3.76** | −3.59** |
aMean (SD) presented for continuous and N(%) presented for categorical variables.
bT-tests (t-statistics shown) or ANOVA (F-statistics shown) used for mean comparisons for two- and three-level categorical variables, respectively; Pearson’s correlations reported for continuous variables.
*Indicates P value ≤0.05.
**Indicates P value ≤0.001.
#CDR score indicating cognitively normal n = 1,060 (75.5%) and CDR score indicating dementia n = 6 (0.04%).