Table 3.

Associations of initial and early slopes with later slopes for PF and PA.

	Unadjusted		Adjusteda
	Standardised β (SE)	P value	Standardised β (SE)	P value
Predictive associations
Initial PF value → Early PA slope	−0.10 (0.03)	<0.001	−0.09 (0.03)	0.003
Initial PA value → Early PF slope	−0.03 (0.04)	0.47	−0.02 (0.03)	0.66
Initial PF value → Later PA slope	−0.09 (0.03)	0.01	−0.07 (0.04)	0.05
Initial PA value → Later PF slope	−0.09 (0.04)	0.04	−0.09 (0.03)	0.003
Early PF slope → Later PA slope	−0.03 (0.04)	0.44	−0.02 (0.04)	0.69
Early PA slope → Later PF Slope	−0.04 (0.04)	0.39	−0.03 (0.04)	0.45
Residual correlations
Initial PF value ←→ Initial PA value	−0.16 (0.03)	<0.001	−0.13 (0.03)	<0.001
Early PF slope ←→ Early PA slope	−0.12 (0.03)	<0.001	−0.11 (0.03)	<0.001
Late PF slope ←→ Late PA slope	−0.13 (0.04)	<0.001	−0.12 (0.04)	0.002
Model fit
Root mean square error of approximation (90% confidence Interval)	0.066 (0.062, 0.070)		0.058 (0.055, 0.061)
Comparative fit index	0.95		0.94

Notes: Initial = estimated intercept at year 1; Early slope = linear slope from year 1 to year 5 (using time points 1–5); Late slope = linear slope from year 5 to year 9 (using time points 5–9).

^aAll paths adjusted for baseline age, baseline MMSE, baseline CDR and baseline hypertension. Late slopes are additionally adjusted for year 9 CDR.