Table 2.
The chance of a biochemical pregnancy and a clinical pregnancy in women with hyperthyroidism and hypothyroidism after assisted reproductive technology (ART) treatments (embryo transfers), during the study period of 1 January 1994 to 30 June 2017
| Exposed cohort (embryo transfers in women with hyperthyroidism) | Unexposed cohort (embryo transfers in women without thyroid disease) | Crude OR (95% CI) | Adjusted OR (95% CI)a | |
|---|---|---|---|---|
| Biochemical pregnancy (hCG),b N (%) | ||||
| Yes | 610 (30.65) | 68,627 (35.63) | 0.78 (0.70–0.87) | 0.80 (0.69–0.93) |
| No | 1,380 (69.35) | 123,992 (64.37) | ||
| Clinical pregnancy (ultrasound),c N (%) | ||||
| Yes | 345 (76.67) | 33.675 (82,22) | 0.69 (0.54–0.88) | 0.74 (0.58–0.96) |
| No | 105 (23.33) | 7,280 (17.78) | ||
| Exposed cohort (embryo transfers in women with hypothyroidism) | Unexposed cohort (embryo transfers in women without thyroid disease) | Crude OR (95% CI) | Adjusted OR (95% CI)a | |
| Biochemical pregnancy (hCG),d N (%) | ||||
| Yes | 1,318 (36.48) | 68,627 (35.63) | 1.05 (0.97–1.13) | 1.05 (0.97–1.14) |
| No | 2,295 (63.52) | 123,992 (64.37) | ||
| Clinical pregnancy (ultrasound),e N (%) | ||||
| Yes | 1,012 (81.55) | 33,674 (82.22) | 0.95 (0.80–1.11) | 0.95 (0.81–1.12) |
| No | 229 (18.45) | 7,281 (17.78) |
Notes: aAdjusted for Charlson index, women’s age, calendar year of treatment, type of treatment (IVF, ICSI, FER/WBR), cause of infertility (female factor, male factor, or mixture of factors/idiopathic). bNumber of embryo transfers in the exposed cohort: 1,990 (number of women: 697, number of missing: 20). Number of embryo transfers in the unexposed cohort: 192,619 (number of women: 65,486, number of missing: 1,353). cRestricted to 2006–June 2017 due to only valid data on ultrasound from 2006. Number of embryo transfers in the exposed cohort: 450 (number of women: 328) missing/not measured: 1,093. Number of embryo transfers in the unexposed cohort: 40,955 (number of women: 28,364) missing/not measured: 76,663. dNumber of embryo transfers in the exposed cohort: 3,613 (number of women: 1,399, number of missing: 79). Number of embryo transfers in the unexposed cohort: 192,619 (number of women: 65,486 number of missing: 1,353). eRestricted to 2006–June 2017 due to only valid data on ultrasound from 2006. Number of embryo transfers in the exposed cohort: 1,241 (number of women: 3,499) missing/not measured: 2,213. Number of embryo transfers in the unexposed cohort: 40,955 (number of women: 28,364) missing/not measured: 76,663.