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. 2019 Aug 7;10:1888. doi: 10.3389/fimmu.2019.01888

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Copyright © 2019 Niu, Zhou, Su, Wang, Xu, Yi, Wu, Du and Ren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in LAG3 and PD-1 expression on CD4 and CD8 T cells over the course of acute sepsis. The lines connect values at enrollment and the 5th day after the onset of sepsis or on the 5th day in the control group. The positive proportion and MESF values were obtained as described in the procedures. Scattergram (A) showed the expression changes of LAG3 and PD-1 on CD4 and CD8 Tcells, respectively. Representative flow cytometry pictures of sepsis group from day 1 to day 5 (B). As there were no significant changes in the control group from day 1 to day 5, we did not present representative images. P-values were calculated with a 2-tailed, non-parametric Wilcoxon matched pairs test.