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. 2019 Aug 7;10:1888. doi: 10.3389/fimmu.2019.01888

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Copyright © 2019 Niu, Zhou, Su, Wang, Xu, Yi, Wu, Du and Ren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Determination of the coexpression of LAG3 and PD-1 on CD4 and CD8 T cells over the course of acute sepsis. Peripheral blood was collected at enrollment and again 5 days later from patients with sepsis and normal controls. We could directly observe T cells with high expression of LAG3 and PD-1 by immunofluorescence (C). After analysis by flow cytometry for the expression of the indicated markers on CD4- and CD8-positive T cells, the ratio of CD8⁺ T cells with LAG3 and PD-1 coexpression was close to 25% and higher than that of CD4⁺ T cells, which was approximately 8% (A); ***P < 0.05 CD4⁺ T cells vs. CD8⁺ T cells in sepsis (B). However, both ratios were significantly higher than those for the control group; *P < 0.05 and **P < 0.05, respectively (B). Data are presented as mean ± SEM, Student's t-test was employed.