Figure 2.

Treatment effects on the MCTD epigenetic associations. (A–D) Effect size correlation plots to compare results from different models. (A) In the x-axis results from linear models in which the treatments are not included as covariates are depicted. In the y-axis results from linear models in which treatments are included as covariates are depicted. (B–D) Effect size comparisons for treatment-stratified analyses comparing effect sizes in the treated sample and in the untreated sample. (E–H) Boxplots for immunosuppressive specific epigenetic signals. DNAm levels are illustrated in controls, MCTD cases, untreated MCTD cases and treated MCTD cases in different CpG sites.