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. 2019 Aug 7;10:1880. doi: 10.3389/fimmu.2019.01880

Table 2.

Top variable methylated sites in MCTD epigenome-wide analysis.

CpG site Position Gene MCTDvar CTRLvar LevTest P
cg01028142 2:7004578 CMPK2 0.172 0.015 223.8 1.0 × 10−37
cg21549285 21:42799141 MX1 0.287 0.053 217.9 5.4 × 10−37
cg08122652 2:122281939 PARP9; DTX3L 0.214 0.033 216.4 8.3 × 10−37
cg24678928 4:169240829 DDX60 0.186 0.033 195.8 3.4 × 10−34
cg07815522 3:122282157 PARP9; DTX3L 0.227 0.042 192.4 9.4 × 10−34
cg08888522 2:163172908 IFIH1 0.141 0.023 186.4 5.6 × 10−33
cg13304609 1:79085162 IFI44L 0.125 0.035 184.9 8.9 × 10−33
cg24298610 21:42796936 MX1 0.090 0.025 179.9 4.1 × 10−32
cg22930808 3:122281881 PARP9; DTX3L 0.236 0.045 174.9 1.9 × 10−31
cg05883128 4:169239131 DDX60 0.151 0.041 169.2 1.1 × 10−30
cg08926253 11:614761 IRF7 0.131 0.040 165.1 4.3 × 10−30
cg13155430 21:42795929 MX1 0.146 0.021 162.8 8.8 × 10−30
cg22862003 21:42797588 MX1 0.180 0.046 160.5 1.8 × 10−29
cg06708931 8:144103857 Intergenic 0.100 0.015 145.7 2.3 × 10−27
cg25998594 14:24632095 IRF9 0.097 0.023 145.6 2.4 × 10−27
cg06033320 8:66750110 PDE7A 0.165 0.066 134.6 9.7 × 10−26
cg12037516 11:614954 IRF7 0.075 0.022 130.5 4.0 × 10−25
cg05552874 10:91153143 IFIT1 0.180 0.054 119.4 1.9 × 10−23
cg03038262 11:315262 IFITM1 0.140 0.057 119.2 2.1 × 10−23
cg01079652 1:79118191 IFI44 0.177 0.034 117.3 4.2 × 10−23
cg22016995 11:614787 IRF7 0.114 0.012 117.2 4.2 × 10−23
cg21995613 8:144106922 Intergenic 0.121 0.047 116.1 6.3 × 10−23
cg12906975 8:144105259 Intergenic 0.066 0.012 108.9 8.5 × 10−22
cg13452062 1:79088559 IFI44L 0.327 0.040 108.9 8.5 × 10−22
cg16400320 8:144105210 Intergenic 0.063 0.019 108.2 1.1 × 10−21
cg11702942 8:144102584 LY6E 0.089 0.034 106.7 1.9 × 10−21
cg25984164 1:174844560 RABGAP1L 0.142 0.065 104.3 4.5 × 10−21
cg14293575 22:18635460 USP18 0.184 0.028 97.0 7.1 × 10−20
cg14864167 8:66751182 PDE7A 0.200 0.073 96.2 9.6 × 10−20

MCTDvar represents DNA methylation variability in MCTD cases measured as its standard deviation.

CTRLvar represents DNA methylation variability in controls measured as its standard deviation.

LevTest represents the test statistic obtained in the Levene's test.

P is the P value obtained for Levene's test comparing variance between MCTD cases and controls in DNAm residuals after adjusted by age, sex, batch effects, and estimated cell proportions.

Genomic positions are based on the hg19 human reference sequence build (GRCh37).