Table 3.
Treatment stratification epigenetic association results for immunosuppressive therapy.
| Discovery sample (EPIC) | Replication sample (450K) | |||||
|---|---|---|---|---|---|---|
| CpG site | Position | Gene | Treated β (P) | Untreated β (P) | Treated β (P) | Untreated β (P) |
| cg01721555 | 3:122401300 | PARP14 | −0.01 (0.072) | −0.03 (4.5 × 10−12) | −0.01 (0.208) | −0.04 (2.0 × 10−04) |
| cg03035167 | 2:201336269 | SPATS2L | 0.01 (0.238) | 0.05 (6.9 × 10−10) | 0.02 (0.019) | 0.05 (3.0 × 10−06) |
| cg03848588 | 9:32525008 | DDX58 | −0.01 (0.149) | −0.04 (4.4 × 10−15) | −0.01 (0.043) | −0.03 (1.8 × 10−04) |
| cg07253769 | 12:113447342 | OAS2 | 0.03 (0.014) | 0.07 (4.2 × 10−12) | 0.02 (0.171) | 0.06 (4.3 × 10−04) |
| cg18686270 | 3:146258875 | PLSCR1 | −0.01 (0.177) | −0.04 (4.4 × 10−11) | −0.01 (0.396) | −0.07 (5.9 × 10−04) |
| cg23892836 | 6:29692085 | HLA-F | −0.04 (0.016) | −0.07 (2.6 × 10−10) | −0.04 (0.012) | −0.07 (4.6 × 10−04) |
| cg25178683 | 17:76976267 | LGALS3BP | −0.02 (0.198) | −0.11 (3.6 × 10−16) | −0.04 (0.026) | −0.07 (5.3 × 10−04) |
Treated β (P) represents the DNA methylation differences between treated MCTD cases and controls.
Untreated β (P) represents the DNA methylation differences between untreated MCTD cases and controls.
P represents the P-value obtained from in the linear regression model adjusted by age, sex, batch effects, and estimated cell proportions.
Genomic positions are based on the hg19 human reference sequence build (GRCh37).