Table 4.

The fifteen most perturbed genes among 47 Vitamin D-induced biosets

Gene ID	Gene Name	Specificity	Evidence of association with AD- or schizophrenia - related phenotypes
			Phenotype	SNP	Reported p value*	Ref.
CYP24A1	cytochrome P450, family 24, subfamily A, polypeptide 1	33 (32 up/1 down)/47
EFTUD1	elongation factor Tu GTP binding domain containing 1	28(27 up/1 down)/47	cognitive ability	rs867371	1 × 10−10	(40)
				rs2134046	2 × 10−8	(40)
			Intelligence	rs28420834	1 × 10−10	(41)
				rs1972460	2 × 10−10	(41)
				rs2665103	4 × 10−10	(41)
				rs12439619	1 × 10−8	(41)
			educational attainment	rs28420834	3 × 10−10	(42)
			left superior temporal gyrus thickness in schizophrenia patients	rs1466921	9 × 10−7	(43)
CD14	CD14 molecule	27(26 up/1 down)/47
CLMN	calmin (calponin-like, transmembrane)	27(26 up/1 down)/47	Cognitive decline in AD patients	rs115102486	2 × 10−8	(44)
			response to perphenazine treatment	rs1187614	2 × 10−7	(45)
MAPK13	mitogen-activated protein kinase 13	24(23 up/1 down)/47
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	24(23 up/ 1 down)/47	cerebrospinal fluid Aβ1–42 levels	rs316341	2 × 10−8	(46)
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	23(22 up /1 down)/47
THBD	Thrombomodulin	22 (21 up /1 down)/47
G0S2	G0/G1switch 2	22(21 up /1 down)/47
GEM	GTP binding protein overexpressed in skeletal muscle	22(21 up / 1 down)/47
CD97	CD97 molecule	22(22 up)/47
ACVRL1	activin A receptor type II-like 1	21(17 up/ 4 down)/47
GRK5	G protein-coupled receptor kinase 5	21(19 up /2 down)/47
HBEGF	heparin-binding EGF-like growth factor	20(18 up /2 down)/47	AD risk	rs11168036	7 × 10−9	(47)
			Intelligence	rs2282802	5 × 10−9	(41)
				rs2074613	1 × 10−8	(41)
FOSL2	FOS-like antigen 2	20(18 up/2 down)/47

^*Reported p values were from literature (listed in Ref. column) reported genome-wide significance analysis (GWAS) studies.