Table 3.
Food anticipatory activity in hormone mutant mice.
| Gene disrupted | Line | Strain | RF phase (ZT) | Output | FAA during RF | FAA during fasting | References |
|---|---|---|---|---|---|---|---|
| ob/ob | Global | C57BL/6J | 12-16, then 4-8 | Wheel & home-cage activity | Enhanced | Present | (Ribeiro et al., 2011) |
| ob/ob | Global | C57BL/6J | 10; 60% CR1 | Behavior recorded by video | Present, but some behaviors reduced | ND | (Gunapala et al., 2011) |
| SGhsr | Global (Regeneron) | C57BL/6 | 6-14 | Wheel | Attenuated | Attenuated | (LeSauter et al., 2009) |
| C57BL/6J x DBA | 4-8 | Wheel; infrared beam | Attenuated2 | Attenuated | (Blum et al., 2009) | ||
| Global (AstraZeneca) | C57BL/6 | 12-14 | Wheel | Attenuated | ND | (Verhagen et al., 2011) | |
| Global (Zigman & Elmquist) | C57BL/6J | 12:00-16:00 (no ZT given) | Photobeam breaks | Absent | ND | (Davis et al., 2011) | |
| Preproghrelin | Global | C57BL/6J | 4-8 | Telemetry | Present | ND | (Szentirmai et al., 2010) |
| Ghrelin | Global | C57BL/6J x SJL/J | 10; 60% CR1 | Behavior recorded by video | Present | ND | (Gunapala et al., 2011) |
| Mc3r | Global | C57BL/6 | 7-11; 50% CR | Wheel & spontaneous activity (CLAMS) | Attenuated | ND | (Sutton et al., 2008) |
| Mc3r & ob/ob | Global | C57BL/6J | 4-8 | Wheel | Enhanced | ND | (Ribeiro et al., 2011) |
| Mc4r | Global | C57BL/6 | 7-11; 50% CR | Wheel | Present | ND | (Sutton et al., 2008) |
| Mchr1 | Global | F3 C57BL/6J x 129SvEv | 5-9 | Wheel | Present | ND | (Zhou et al., 2005) |
All experiments were performed in 12L:12D unless otherwise indicated. All mice had intact (not lesioned) SCN unless otherwise indicated. RF: restricted feeding; FAA: food anticipatory activity; ND: not determined; CR: caloric restriction
Note that data collected under conditions of restricted feeding with purposeful caloric restriction are not presented herein
1
Experiments were performed in 13L:11D
2
FAA was also present in constant darkness (Lamont et al., 2014)