Table 5.
Food anticipatory activity in other mutant and engineered mice.
| Gene disrupted | Line | Strain | RF phase (ZT) | Output | FAA during RF | FAA during fasting | References |
|---|---|---|---|---|---|---|---|
| Prokineticin2 | Global | C57BL/6 × 129/Ola | 3-7 | Infrared beam breaks | Present | Present | (Li et al., 2006) |
| Vipr2 | Global | C57BL/6J | 4-8 | Wheel | Present | ND | (Sheward et al., 2007) |
| PAC1 receptor | Global | 129 | 4-8 | Wheel | Present1 | ND | (Hannibal et al., 2016) |
| Poly(ADP-Ribose) Polymerase 1 | Global | C57BL/6J | 3-9 | Wheel | Present | ND | (Asher et al., 2010) |
| Sirt1 | Global | FVB (N6) | 6-10 | Wheel | Attenuated | ND | (Satoh et al., 2010) |
| Global | CD1 | 7; 60% CR | Video | Present | ND | (Assali et al., 2018) | |
| Y/Y mutant, Global, no catalytic activity | CD1 | 7; 60% CR | Video | Present | ND | (Assali et al., 2018) | |
| CAGG-Cre-ER floxed (global in adulthood) | C57BL/6 | 9; 60% CR | Video | Present | ND | (Assali et al., 2018) | |
| Tyrosine hydroxylase-Cre floxed | C57BL/6 | 9; 60% CR | Video | Present | ND | (Assali et al., 2018) | |
| Pomc-Cre floxed | FVB/N x C57BL/6J x 129 | 9; 60% CR | Video | Present | ND | (Assali et al., 2018) | |
| Nestin-Cre floxed | C57BL/6J | 9; 60% CR | Video | Present | ND | (Assali et al., 2018) | |
| CamKII-alpha-Cre floxed | C57BL/6 | 9; 60% CR | Video | Present | ND | (Assali et al., 2018) | |
| Sirt1 over-expression | Brain (BRASTO) | C57BL/7J | 6-10 | Wheel | Enhanced | ND | (Satoh et al., 2010) |
| Grid2 ho/ho | Hotfoot mutation (ho/ho) | C57BL/6J | 6-12 | Wheel and telemetry | Attenuated | ND | (Mendoza et al., 2010) |
| Human Huntington Disease gene with CAG repeats | R6/2 | C57BL/6 x CBA F1 | 6-11 | Infrared sensors | Present | ND | (Maywood et al., 2010) |
| Rgs16 | Global | C57BL/6J | 6-10 | Area sensor | Attenuated | ND | (Hayasaka et al., 2011) |
| PKCγ | Global | C57BL/6 × 129SvJ | 6-10 | Wheel | Present | ND | (Zhang et al., 2012) |
| Wolfram syndrome 1 | Global | 129 Sv/EvTac | 4-8 | Wheel | Present | ND | (Luuk et al., 2012) |
| Tissue-type plasminogen activator | Global | C57BL/6J | 6-10 | Wheel | Present | ND | (Krizo et al., 2018) |
All experiments were performed in 12L:12D unless otherwise indicated. All mice had intact (not lesioned) SCN unless otherwise indicated. RF: restricted feeding; FAA: food anticipatory activity; ND: not determined; CR: caloric restriction
1
FAA was also present in constant dim red light