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Structure of Argonaute. (a) Argonaute proteins are organized in 4 domains that are well-conserved from yeast to humans (>25% identity between S. pombe and H. sapiens). (b) Structure of human Argonaute (Ago2) in complex with miR-20a showing the binding of MID to the 5ʹ end of the small RNA, and of PAZ to the 3ʹ end [97].
