Figure 1.

ASPACT is highly expressed during viral infection. a Gene structure and orientation of ASPACT and PACT genes. The ASPACT gene encodes three splice variants: V1, V2, and V3 (identified exons shown as black rectangles). The arrows were represented as the orientation of transcription for ASPACT and PACT. b–e Expression levels of ASPACT and PACT were profiled on the basis of various microarray datasets archived in the GEO. Alterations in the indicated biological contexts are shown by box plots: b, d blood samples from patients with acute DENV infection (n = 18), during convalescence (n = 19), and healthy controls (n = 9); c, e well-differentiated primary lung bronchial epithelial cells 36 h after infection with seasonal H1N1 BN/59, pandemic H1N1 KY/136 and KY/180 (n = 3). In all panels, data represent the mean and SEM (error bars). Significant differences were verified by Student’s t test (ns: P > 0.05, *: P < 0.05, **: P < 0.01, ***: P < 0.001).