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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Neuropharmacology. 2019 Jun 28;157:107691. doi: 10.1016/j.neuropharm.2019.107691

Figure 4. Observed on -rate and off-rate kinetics for α-Ctx VnIB on the α6/α3β4 nAChR.

Figure 4

Representative curves for the observed on-rate and off-rate of 20 nM α-Ctx VnIB flow-applied on Xenopus laevis oocytes expressing the α6/α3β4 nAChR. Washout data were averaged from a total of 10 oocytes. The half-time (t½) of the blocking effect is 0.87 min−1 and t½ for recovery after washout of the toxin is 2.7 min-1.