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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Neuropharmacology. 2019 Jun 28;157:107691. doi: 10.1016/j.neuropharm.2019.107691

Figure 5. Washout of VnIB-mediated block of α6/α3β4 and α6/α3β2β3 nAChRs.

Figure 5

Representative washout traces from recordings on Xenopus laevis oocytes expressing α6/α3β4 and α6/α3β2β3 nAChRs. Oocytes were stimulated with 1 s pulses of ACh at 1 min intervals during the washout of 100 nM α-Ctx VnIB. (A) α-Ctx VnIB reduced ACh-evoked currents through α6/α3β4 by ~85%, and the currents recovered to the original amplitude levels after 8 min washout. (B) α-Ctx VnIB reduced ACh-evoked currents through α6/α3β2β3 by ~10%, and the currents recovered to the original amplitude levels after 1 min of washout.