Table 2. Amino acid sequences and nAChR selectivity profiles of various α-Ctxs.

Based on previously published data, up to four nAChRs subtypes, at which the given α-Ctxs has the highest potencies, are shown. α6 given in the table refers to the α6/α3 chimera. “≈” indicates a difference in IC₅₀ < 2.5-fold. r, rat; m, mouse; ND, not determined.

α-Ctx	Species	Sequence	nAChR preference
VnIB	C. ventricosus	GGCCSHPVCYTKNPNCG#	rα6β4 > rα3β4 >> rα6β2β3a
Vn1A	C. ventricosus	GGCCSYPPCAVSNPQHC	NDb
AuIB	C. aulicus	GCCSYPPCFATNPDC#	rα3β4 > rα6β4 ≈ rα7c
TxID	C. textile	GCCSHPVCSAMSPIC#	rα3β4 > rα6β4 >> rα2β4d
BuIA	C. bullatus	GCCSTPPCAVLYC#	rα6β2β3 > rα6β4 > rα3β2 > rα3β4e
MII	C. magus	GCCSNPVCHLEHSNLC#	rα6β2β3 >/≈ rα3β2f > rα6β4‡
PIA	C. purpurascens	RDPCCSNPVCTVHNPQIC#	rα6β2β3 > rα6β4 >/≈ rα3β2 > rα3β4g
TxIB	C. textile	GCCSDPPCRNKHPDLC#	rα6β2β3h
OmIA	C. omaria	GCCSHPACNVNNPHICG#	rα3β2 >/≈ rα7 > rα6β2β3i
PeIA	C. pergrandis	GCCSHPACSVNHPELC#	rα9α10 >/≈ rα3β2 ≈ rα6β2β3 > rα6β4j
GI	C. geographus	ECCNPACGRHYSC#	mα1β1γδk

^#C-terminal amidated

^‡Unpublished data

Data from:

^athis work

^b(Romeo et al., 2008)

^c(Luo et al., 1998; Smith et al., 2013)

^d(Luo et al., 2013b)

^e(Azam et al., 2005; Azam et al., 2010)

^f(Cartier et al., 1996; Dowell et al., 2003; McIntosh et al., 2004)

^g(Dowell et al., 2003)

^h(Luo et al., 2013a)

ⁱ(Talley et al., 2006)

^j(Hone et al., 2012b; McIntosh et al., 2005)

^k(Johnson et al., 1995)