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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Immunol Rev. 2019 Sep;291(1):190–213. doi: 10.1111/imr.12792

Figure 6.

Figure 6

Breaching immunological tolerance is critical to B cell transformation. (A) Frequency of IgVH4–34 expression within DLBCL gene expression subgroups (left) and genetic subtypes (right); (B) or within patients with indicated mutation; (C) or within patients with combined genetic alterations. The number of IgVH4–34+ patients within each classification is shown above each bar; p-values are listed in parentheses from Fisher’s exact test. (D) A model for how BCR and/or MYD88 mutations help to overcome mechanisms of B cell tolerance/anergy that normally silence low-affinity autoreactive BCRs. Data for panels A-C are taken from ref. (37) and ref. (48). Frequencies were normalized to reflect predicted population-based frequencies using gene expression subgroup distributions (201) as described (37).