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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Immunol Rev. 2019 Sep;291(1):190–213. doi: 10.1111/imr.12792

Figure 7.

Figure 7

Genetic alterations of BCR pathway genes promote BCR signaling in DLBCL. (A) Frequency of gain-of-function (red) and loss-of-function (green) genetic alterations that affect the BCR pathway. (B) Oncoprint representation of the presence of genetic alterations in common BCR pathway genes in DLBCL. DLBCL subtypes and genetic classes are depicted. Cases lacking these alterations are not shown. The prevalence of BCR pathway mutations in (C) all DLBCL samples, (D) in ABC, GCB and Unclassified forms of DLBCL, or (E) within defined genetic subtypes of DLBCL. Data for panels B-E are taken from ref. (37). Frequencies in panels C-E were normalized to reflect predicted population-based frequencies using gene expression subgroup distributions (201) as described (37).