Figure 6:

Conserved and diet-dependent markers of EC subpopulations. a) Unaligned normal- and Western diet EC scRNAseq profiles represented in a PCA-based space with t-SNE. b) Aligned normal- and Western diet scRNAseq profiles represented with CCA and t-SNE. c) Conserved subpopulations of ECs identified in both datasets. d) Conserved diet-independent markers of EC subpopulation and pan-subpopulation markers of diet-induced change. Diet-independent subpopulation markers are the same as those identified previously while Western diet induces contractile proteins Myl9, Tagln, and Acta2 in all EC subpopulations.