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. Author manuscript; available in PMC: 2020 Jul 9.
Published in final edited form as: Circulation. 2019 May 31;140(2):147–163. doi: 10.1161/CIRCULATIONAHA.118.038362

Figure 8:

Figure 8:

Expression of aortopathy genes by cell identity. a) Expression of thirty genes associated with Mendelian aortopathy by cell type. The majority of these genes have highest expression in VSMCs. Several show highest expression in fibroblasts. Two genes (Mat2a and Notch1) have highest expression in ECs. b) Ternary plot to show expression of aortopathy genes in ECs, VSMCs, and fibroblasts. Several genes are exclusively expressed in VSMCs, while the majority show expression predominantly in VSMCs and fibroblasts. Genes with contractile function are in green, TFGb response genes are in red, ECM-related genes are in blue, and unassigned genes are in black. EC indicates endothelial cells; Fibro, fibroblasts; VSMC, vascular smooth muscle cells.