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. 2019 Jun 28;12(7):e007294. doi: 10.1161/CIRCEP.119.007294

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© 2019 The Authors.

Circulation: Arrhythmia and Electrophysiology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Effect of mono-2-ethylhexyl phthalate (MEHP) on ECG characteristics during sinus rhythm. A, Experimental protocol timeline; all ECG recordings were performed during sinus rhythm. B, ECG signals collected from excised, intact rat hearts with PR interval denoted. C, Heart rate (HR) decreased with time of perfusion and after application of blebbistatin for mechanical uncoupling, with no difference between treatment groups. D, Similar rate slowing was observed in the RR interval, and coincided with heart rate variability changes in E SD of the normal RR intervals (SDNN) and (F) root means successive square difference (rMSSD) after 30-min perfusion. G and H, Prolonged depolarization and repolarization in MEHP-exposed hearts as measured from R to J inflection point (RJ_point) and R to T-wave (RT) (G) PR interval time was significantly lengthened in MEHP-exposed hearts compared to both baseline and control (Ctrl) hearts after the same duration of perfusion (P<0.05). n≥7 per group. BPM indicates beats per minute; and EP, electrophysiology protocol.