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. 2019 Jun 28;12(7):e007294. doi: 10.1161/CIRCEP.119.007294

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© 2019 The Authors.

Circulation: Arrhythmia and Electrophysiology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 3. — Mono-2-ethylhexyl phthalate (MEHP) causes action potential morphology changes with corresponding modification of the electrical restitution curve. A, MEHP exposure caused the restitution curve to change from a biphasic form to a monophasic form with no plateau phase. The slope of the plateau on the control (Ctrl) heart was 0.06 compared with 0.18 in the MEHP hearts. B, Despite the similarities in the action potential duration at faster cycle lengths, the ventricular effective refractory period (VERP) was markedly prolonged in the MEHP-treated group (P<0.05). C, With rapid pacing (pacing cycle length [PCL]=140 ms), the action potential duration (APD) appeared similar between the Ctrl and MEHP-treated groups: there were no difference between (D) APD30, (E) APD90, or (F) AP triangulation. G, At slower cycle lengths (PCL=240 ms), the action potential morphology was quite different: while (H) APD30 was similar, (I) lengthening was apparent in the late phase as shown by APD90 (P<0.05). J, The effect on APD90 with no change on APD30 caused an increase in the triangulation shape of the AP after MEHP treatment (P<0.05). N=7 for each group. AP Tri indicates action potential triangulation; and Vm, transmembrane voltage.