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. 2019 Jun 28;12(7):e007294. doi: 10.1161/CIRCEP.119.007294

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© 2019 The Authors.

Circulation: Arrhythmia and Electrophysiology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 4. — Action potential alternans and arrhythmia susceptibility from mono-2-ethylhexyl phthalate (MEHP) exposure. A, MEHP-treated hearts displayed increased susceptibility to alternating action potential morphology at the same pacing cycle length (PCL) compared with baseline as predicted by the change in electrical restitution (See Figure 3A), PCL=110 ms this example. B, The longest PCL which resulted in alternating action potentials (alternans threshold) was longer in the MEHP-treated hearts (P=0.06). C, Hearts after MEHP exposure became more susceptible to spontaneous arrhythmia as shown by a higher incidence of both premature ventricular contractions (PVC) and ventricular tachycardia or ventricular fibrillation (VT/VF) following electrophysiological study (P<0.0001, χ² test). N=8 for each group. AUF indicates arbitrary units of fluorescence; and Ctrl, control.