Table 1. Summary results of Bayesian random-effect and meta-regression models on birth outcomes affected by maternal influenza vaccination.
Birth outcomes | Bayesian random-effect model | Bayesian random-effect meta-regression model | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Study | Odds ratio | P (OR<1) |
Odds ratio (vaccination season) |
P (OR<1) |
Odds ratio (income level) |
P (OR<1) |
|||||||
Posterior median | 95% CrI | Posterior median | 95% CrI | Posterior median | 95% CrI | ||||||||
PTB | SD (τ) | 0.094 | 0.101 | 0.086 | |||||||||
Overall | 0.945 | 0.736 | 1.345 | 0.733 | 0.837 | 0.566 | 1.278 | 0.844 | 1.019 | 0.784 | 1.364 | 0.414 | |
RCT overall | 0.954 | 0.787 | 1.224 | 0.707 | 0.847 | 0.606 | 1.201 | 0.848 | 1.003 | 0.816 | 1.260 | 0.484 | |
Cohort overall | 0.916 | 0.859 | 0.977 | 0.995 | 0.798 | 0.608 | 1.029 | 0.960 | 1.016 | 0.905 | 1.143 | 0.393 | |
Case-control overall | 0.970 | 0.762 | 1.439 | 0.601 | 0.868 | 0.593 | 1.369 | 0.765 | 1.039 | 0.804 | 1.449 | 0.359 | |
LBW | SD (τ) | 0.107 | 0.119 | 0.120 | |||||||||
Overall | 0.928 | 0.432 | 2.112 | 0.766 | 0.508 | 0.045 | 4.655 | 0.714 | 0.952 | 0.405 | 2.335 | 0.642 | |
RCT overall | 0.926 | 0.721 | 1.238 | 0.800 | 0.500 | 0.066 | 3.669 | 0.727 | 0.938 | 0.714 | 1.301 | 0.723 | |
Cohort overall | 0.932 | 0.864 | 0.998 | 0.978 | 0.521 | 0.072 | 3.736 | 0.715 | 0.966 | 0.786 | 1.165 | 0.644 | |
SGA | SD (τ) | 0.123 | 0.124 | 0.125 | |||||||||
Overall | 0.971 | 0.249 | 4.217 | 0.633 | 1.202 | 0.273 | 4.783 | 0.728 | 0.975 | 0.205 | 4.482 | 0.608 | |
RCT overall | 0.964 | 0.475 | 2.010 | 0.666 | 1.189 | 0.538 | 2.685 | 0.264 | 0.965 | 0.478 | 2.051 | 0.653 | |
Cohort overall | 0.976 | 0.947 | 1.004 | 0.955 | 1.211 | 0.798 | 1.892 | 0.851 | 0.981 | 0.927 | 1.039 | 0.768 | |
Con-genital mal-formation | SD (τ) | 0.100 | 0.103 | 0.102 | |||||||||
Overall | 1.026 | 0.687 | 1.600 | 0.380 | 1.383 | 0.814 | 2.459 | 0.086 | 1.005 | 0.643 | 1.577 | 0.480 | |
RCT overall | 1.032 | 0.659 | 1.709 | 0.390 | 1.393 | 0.795 | 2.576 | 0.095 | 1.002 | 0.610 | 1.621 | 0.494 | |
Cohort overall | 1.026 | 0.955 | 1.108 | 0.220 | 1.384 | 0.961 | 2.058 | 0.040 | 1.007 | 0.891 | 1.173 | 0.451 | |
Case-control overall | 1.022 | 0.706 | 1.499 | 0.410 | 1.374 | 0.827 | 2.347 | 0.087 | 1.004 | 0.677 | 1.504 | 0.487 | |
Fetal death | SD (τ) | 0.222 | 0.191 | 0.203 | |||||||||
Overall | 0.942 | 0.560 | 1.954 | 0.616 | 0.732 | 0.372 | 1.681 | 0.821 | 0.977 | 0.578 | 1.885 | 0.550 | |
RCT overall | 1.002 | 0.686 | 1.679 | 0.497 | 0.767 | 0.414 | 1.525 | 0.791 | 1.023 | 0.693 | 1.673 | 0.454 | |
Cohort overall | 0.822 | 0.718 | 0.931 | 0.996 | 0.643 | 0.391 | 1.100 | 0.951 | 0.857 | 0.655 | 1.102 | 0.919 | |
Case-control overall | 1.077 | 0.719 | 1.833 | 0.385 | 0.814 | 0.433 | 1.672 | 0.726 | 1.098 | 0.724 | 1.832 | 0.343 |
CrI: Credible Interval,
SD (τ): Standard deviation between studies (estimation of heterogeneity between studies)