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. 2019 Aug 2;13(8):e0007601. doi: 10.1371/journal.pntd.0007601

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© 2019 Wei et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — (A and B) Pigs (n = 40) were immunized with SA14-14-2 vaccine and serum samples for each animal were collected at 30 days post-vaccination for detection of neutralizing antibodies against SA14-14-2, N28(GIII) and SD12(GI) strains. (A) Seropositive rate against the indicated JEV strains. ***, p < 0.001 detected by Fisher’s exact test. (B) Neutralizing antibody titers (PRNT₅₀) against the indicated JEV strains were measured on BHK-21 cells and plotted. A p value was generated by Student’s t-test. (C, D and E) Mice (n = 10) were immunized with the SA14-14-2 vaccine and serum samples were collected at 14 days post-vaccination for detection of neutralizing antibodies against SA14-14-2 vaccine, N28(GIII) and SD12(GI) strains. (C) PRNT₅₀ titers in serum samples collected from pre-vaccinated mice. (D) PRNT₅₀ titers against the indicated JEV strains in serum samples collected from vaccinated mice. A p value was generated by Student’s t-test. (E) Seropositive rate against the indicated JEV strains. ***, p < 0.001, **, p < 0.01 detected by Fisher’s exact test.