Table 2.
Hazard ratio (HR) and 95% confidence intervals (CIs) for the association between menopausal status and any first CHD event
| Post-menopausal vs pre-menopausal |
|||
|---|---|---|---|
| Model | HR (95% CI) | p-value | PE% (95% CI)a |
| Age-adjusted model | 1.23 (1.08–1.40) | 0.002 | / |
| Confounder-adjusted modelb | 1.13 (0.98–1.30) | 0.09 | 40.5 (30.4–54.6) |
| Confounder- and intermediate-adjusted modelc | 1.08 (0.93–1.26) | 0.29 | 60.7 (54.4–80.6) |
N (N of events): post-menopausal 9916 (4074), pre-menopausal 5486 (679).
a
PE, proportion explained.
b
Adjusted for baseline age, smoking status, BMI, HbA1c, education level, physical activity, full-term pregnancy, age at menarche and ever hormone use.
c
Additionally adjusted for high-sensitivity C-reactive protein, total cholesterol, HDL-cholesterol, triglycerides and high blood pressure.