Table 3.
Hazard ratio (HR) and 95% confidence intervals (CIs) for the association between age at menopause and any first CHD event in post-menopausal women
| HR per-year decrease in age at menopause |
HR per SD decrease in age at menopause |
||||
|---|---|---|---|---|---|
| Model | HR (95% CI) | p-value | HR (95% CI) | p-value | PE% (95% CI)a |
| Age-adjusted model | 1.03 (1.02–1.04) | <0.001 | 1.23 (1.15–1.33) | <0.001 | – |
| Confounder-adjusted modelb | 1.02 (1.01–1.03) | <0.001 | 1.16 (1.08–1.25) | <0.001 | 28.6 (23.2–34.5) |
| Confounder- and intermediate- adjusted modelc | 1.02 (1.01–1.03) | 0.001 | 1.14 (1.05–1.23) | 0.001 | 38.7 (30.4–44.6) |
N (N of events): 9916 (4074).
a
PE, proportion explained.
b
Adjusted for baseline age, smoking status, BMI, HbA1c, education level, physical activity, full-term pregnancy, age at menarche and ever hormone use.
c
Additionally adjusted for high-sensitivity C-reactive protein, total cholesterol, HDL-cholesterol, triglycerides and high blood pressure.