Figure 3. PDPN neutralization improves LV function after MI.
Scatter plots representing EF percentage (A), percentage of FS (B), LV end-diastolic diameter (C), and LV end-systole diameter (D) as measured by echocardiography at baseline and at 7 and 30 days after MI in mice treated with PDPN-neutralizing Ab (n = 12/group), isotype-matched IgG (n = 10/group), or saline (n = 12/group). Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, control versus treated at 30 days after MI. #P < 0.05, ##P < 0.01, IgG control versus treated at 30 days after MI. $P < 0.05 control versus IgG control at 30 days after MI. Two-way ANOVA and Bonferroni’s post hoc test were performed among all groups.