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. 2019 Aug 10;3(3):16. doi: 10.3390/epigenomes3030016

Figure 3.

Figure 3

Functional relevance, prognostic value, and cancer specificity of PDAC-associated 5hmC loci. (A) The host genes containing PDAC-associated 5hmC loci are enriched in certain KEGG pathways and GO biological processes relevant to cancer pathobiology (Fisher’s exact test p < 0.01, gene count > 5); (B) Evaluation of prognostic value of PDAC-associated 5hmC loci using a permutation test (n = 100,000), based on the PDAC dataset from the Human Pathology Atlas (HPA) database. The real data point representing the number of PDAC-associated 5hmC loci with survival relevance in the HPA is shown as a red vertical line; (C) Evaluation of pancreatic cancer-specific gene expression of PDAC-associated 5hmC loci using a permutation test (n = 100,000) based on the PDAC dataset from the HPA database. The real data point representing the number of PDAC-associated 5hmC loci with elevated mRNA expression in PDAC in the HPA is shown as a red vertical line.