Table 3.
Associations of the sleep-associated plasma metabolite score with risk of coronary heart disease among post-menopausal women in the Women’s Health Initiative
| Sleep-related metabolite score (SMS)a |
Per SD increase in SMS | P-trend | |||||
|---|---|---|---|---|---|---|---|
| Quintile 1 |
Quintile 2 |
Quintile 3 |
Quintile 4 |
Quintile 5 |
|||
| Odds ratio (95% CI) | |||||||
| Cases/controls | 109/207 | 162/212 | 186/209 | 220/210 | 231/210 | ||
| Model 1b | 1.00 (ref) | 1.46 (1.08, 1.98) | 1.70 (1.26, 2.29) | 1.93 (1.44, 2.60) | 2.08 (1.55, 2.80) | 1.24 (1.13, 1.36) | 4.411E-06 |
| Model 2c | 1.00 (ref) | 1.48 (1.08, 2.03) | 1.59 (1.17, 2.16) | 1.67 (1.23, 2.28) | 1.79 (1.31, 2.45) | 1.16 (1.05, 1.28) | 0.0003 |
| BMI < 25 kg/m2 | 1.00 (ref) | 1.83 (1.11, 3.03) | 1.67 (1.02, 2.75) | 1.91 (1.13, 3.23) | 1.83 (1.05, 3.17) | 1.19 (1.01, 1.41) | 0.04 |
| BMI ≥ 25 kg/m2 | 1.00 (ref) | 1.26 (0.83, 1.91) | 1.48 (0.99, 2.22) | 1.50 (1.00, 2.23) | 1.67 (1.12, 2.50) | 1.14 (1.01, 1.29) | 0.03 |
| Model 3d | 1.00 (ref) | 1.44 (0.97, 2.14) | 1.65 (1.10, 2.46) | 1.89 (1.23, 2.90) | 1.48 (0.91, 2.41) | 1.17 (0.99, 1.37) | 0.06 |
The metabolite score included nine sleep-related metabolites (TAGs 45: 1 48: 1 50: 4, DAG 32: 1, PEs 36: 4 38: 5, PCs 30: 1 40: 6, N6-acetyl-L-lysine).
Model 1: adjusted for matching factors, including age, race/ethnicity, hysterectomy status and enrolment window.
Model 2: Model 1 + adjusted for BMI, smoking, alcohol use, caffeine intake, dietary quality, physical activity, prevalent hypertension, depressive symptoms, current hormone therapy, aspirin use, statin use and other lipid-lowering medications.
Model 3: Model 2 + adjusted for total cholesterol, HDL cholesterol, total triglycerides, fasting glucose and C-reactive protein. As total triglycerides and fasting glucose were not measured on every participant, Model 3 was based on a subset of 1287 participants (629 cases and 658 controls).