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. 2019 Aug 8;4(15):e129397. doi: 10.1172/jci.insight.129397

Figure 2. Manipulation of adipose DNL alters whole-body metabolism.

Figure 2

(AD) Twelve hours after dox injection (2 mg/kg) mice were subjected to an (A) oral glucose tolerance test (n = 6) and a (B) triglyceride clearance test (n = 9–10). At this 12-hour time point, another cohort of mice were used for (C) sWAT and eWAT depot weights (n = 8) and (D) total body weight (n = 8). (EL) Mice were provided with chow diet containing dox for 3 days or 3 weeks, at which time mice were subjected to an (E and I) oral glucose tolerance test (n = 5–8) and a (F and J) triglyceride clearance test (n = 5–8) or (G and K) sacrificed for white AT weights. (H and L) Body weight measurements at the indicated times. (M) qPCR for lipogenic genes in liver of control and ad-Insig1 mice following 3 weeks of chow diet supplemented with dox (n = 7). All data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 by 2-tailed Student’s t test (bar graphs) or 2-way ANOVA (systemic assays).