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. 2019 Aug 8;4(15):e126764. doi: 10.1172/jci.insight.126764

Figure 12. ORC-13661 cotreatment significantly reduces neomycin-Texas Red fluorescence in lateral line hair cell bodies.

Figure 12

Quantification of neomycin-Texas red (neo-TR) fluorescence in the hair cell bodies of brn3c:gfp zebrafish cotreated with 25 μM neo-TR and ORC-13661 (0.10–8.33 μM) for 10 minutes. Each graphed symbol represents 1 hair cell, with 5–16 hair cells sampled from 2–4 neuromasts per fish in 2–4 fish per treatment group. Average fluorescence relative to baseline of hair cell bodies in fish treated with neo-TR alone is significantly greater than that observed in any group cotreated with ORC-13661 (P < 0.001 for all groups). For statistical analysis 1-way ANOVA was used. Error bars represent SD.