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. 2019 Aug 8;4(15):e126764. doi: 10.1172/jci.insight.126764

Figure 3. ORC-13661 prevents hearing threshold shifts in amikacin-treated rats.

Figure 3

Hearing threshold shifts in rats treated with a 10-day course of amikacin [320 mg/(kg.day); subcutaneous injection] with or without concurrent ORC-13661 [0.2, 1, 5 mg/(kg.day); oral administration]. Mean pretreatment to post-treatment shifts in hearing thresholds are reported; positive values indicate increasing levels of hearing loss. Amikacin treatment alone results in a substantial loss of hearing between 4 and 32 kHz; hearing threshold shifts in rats receiving 1 and 5 mg/(kg.day) of ORC-13661 were significantly reduced at 32 kHz (P < 0.05 and P < 0.01, respectively) compared with amikacin alone. Controls were treated with ORC-13661 or saline alone. The number of recordings for each condition was as follows: control, 16; amikacin, 19; ORC-13661 (0.2 mg/kg) + amikacin, 5; ORC-13661 (1 mg/kg) + amikacin, 8; ORC-13661 (5 mg/kg) + amikacin, 7. Within a condition n numbers are the same for each frequency tested. For statistical analysis 2-way ANOVA was used. Error bars represent SEM.