Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 14;5(8):eaax0780. doi: 10.1126/sciadv.aax0780

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

PMC Copyright notice

Fig. 5 — Naïve BALB/c mice (three groups; n = 5 per group) were primed with medroxyprogesterone before intravaginal HSV-2 infection. Starting at day 1 after infection, mice were treated with either topical DECON (alternate days) or systemic ACV (5 mg/kg; every day) by intraperitoneal (IP) injections. (A) Representative stereoscope images of the murine genital region 0 and 7 days after infection. (B) Vaginal swabs collected on days 2, 4, and 7 were overlaid on Vero cells to estimate the extent of virus production through plaque assays. (C) Disease scores were given in a blinded fashion from 0 to 4, with 4 being severe. (D) Kaplan-Meier survival curves for the infected and treated mice. (E) Draining lymph nodes for the infected and treated mice were collected on day 21, washed, photographed, and weighed (F). (Photo credit: Tejabhiram Yadavalli, University of Illinois at Chicago)