Table 1.
Baseline characteristics of patients with baseline gelsolin level below the 25th percentile and the patients above the 25th percentile
| Characteristic | Gelsolin lower quartile (n = 190) | Gelsolin upper quartiles 2–4 (n = 556) | P values for differences |
| Age (year, median, IQR) | 64 (56–73) | 69 (59–76) | 0.001 |
| Gender (n male/n female) | 103 (54.2)/87 (45.8) | 300 (54.0)/256 (46.0) | 1.0 |
| Apache II score (median, IQR) | 21 (16–27) | 20 (14–26) | 0.3 |
| BMI (kg/m2, median, IQR) | 24.8 (22.0–27.8) | 24.7 (22.2–27.7) | 0.5 |
| COPD n (%) | 25 (13.2) | 122 (21.9) | 0.009 |
| Severe sepsis/septic shock n (%) | 116 (61.1) | 184 (33.1) | <0.0001 |
| Surgical origin n (%) | 71 (37.4) | 141 (25.4) | 0.002 |
| Acute thrombosis* n (%) | 4 (2.1) | 29 (5.2) | 0.07 |
| Chronic inflammatory disease† n (%) | 14 (7.37) | 29 (5.2) | 0.3 |
| Procalcitonin (μg/L, median, IQR) | 12.3 (2.8–38.2) | 2.61 (0.5–14.3) | 0.0002 |
| PaO2/FiO2 ratio kPa/mmHg (median, IQR) | 21.0 (13.4–29.3)/157.5 (100.5–219.8) | 19.6 (12.2–29.0)/147.0 (91.5–217.5) | 0.8 |
| SPD (ng/mL, median, IQR) | 94.2 (55.6–172.7) | 135.3 (78.9–314.2) | 0.0002 |
| ARDS n (%) | 10 (3.6) | 20 (5.3) | 0.3 |
| Gelsolin (mg/L, median, IQR) | 29.1 (17.2–42.2) | 90.0 (69.9–115.6) | <0.0001 |
*Acute myocardial infarction, pulmonary embolism, cerebral infarction, mesenteric embolism, and medulla spinalis infarction.
†Rheumatoid arthritis, Sjögren syndrome, fibromyalgia, spondylosis, hepatic cirrhosis, systemic lupus erythematosus, vasculitis, and chronic glomerulonephritis.
ARDS indicates acute respiratory distress syndrome; BMI, body mass index; COPD, chronic obstructive pulmonary disease; IQR, interquartile range; SPD, surfactant protein D.