Table 2.

Predictors of successful weaning from mechanical ventilation within 28 days – Cox regression

	Univariable			Multivariable
Variable	HR	95% CI	P value	HR	95% CI	P value
Age (per year increase)	1.00	0.99–1.00	0.08	1.00	0.99–1.00	0.1
Gender (male/female)	1.03	0.87–1.22	0.7	0.98	0.82–1.17	0.8
Severe sepsis/shock (vs. milder or no infection)	0.62	0.52–0.75	<10–4	0.76	0.62–0.93	0.007
Surgical origin (yes/no)	1.07	0.89–1.28	0.5	1.03	0.85–1.25	0.8
Acute thrombosis* (yes/no)	1.40	0.94–2.09	0.1	1.24	0.82–1.87	0.3
Chronic inflammatory disease† (yes/no)	0.78	0.52–1.15	0.2	0.87	0.58–1.30	0.5
PCT (≥1 μg/L vs. PCT <1 μg/L)	0.61	0.50–0.73	<10–4	0.71	0.58–0.88	0.002
PaO2/FiO2 Q1 (vs. Q2–Q4)	0.77	0.64–0.93	0.007	0.84	0.69–1.02	0.08
SPD (≥85th percentile vs. SPD <85th percentile)	0.79	0.64–0.96	0.02	0.74	0.60–0.92	0.006
COPD (yes/no)	0.96	0.77–1.20	0.7	0.84	0.67–1.06	0.2
Apache II score (<25 vs. ≥25)	0.70	0.58–0.85	0.0004	0.81	0.66–1.00	0.05
Gelsolin Q1 (vs. Q2–Q4)	0.67	0.55–0.82	10–4	0.71	0.58–0.88	0.002

Significant results (P < 0.05) are marked with bold font.

^*Acute myocardial infarction, pulmonary embolism, cerebral infarction, mesenteric embolism, and medulla spinalis infarction.

^†Rheumatoid arthritis, Sjögren syndrome, fibromyalgia, spondylosis, hepatic cirrhosis, systemic lupus erythematosus, vasculitis and chronic glomerulonephritis.

COPD indicates chronic obstructive pulmonary disease; PCT, procalcitonin; Q1, lower quartile; Q2–Q4, upper 3 quartiles; SPD, surfactant protein D.