Table 3.
Predictors of 28 days mortality – Cox regression
| Univariable | Multivariable | |||||
| Variable | HR | 95% CI | P value | HR | 95% CI | P value |
| Age (per year increase) | 1.04 | 1.02–1.04 | <10–4 | 1.03 | 1.02–1.04 | <10–4 |
| Gender (male/female) | 1.18 | 0.93–1.50 | 0.2 | 1.30 | 1.01–1.66 | 0.05 |
| Severe sepsis/shock (vs. milder or no infection) | 1.19 | 0.94–1.51 | 0.2 | 1.12 | 0.86–1.45 | 0.4 |
| Surgical origin (yes/no) | 0.65 | 0.49–0.87 | 0.003 | 0.75 | 0.56–1.03 | 0.07 |
| Acute thrombosis* (yes/no) | 1.56 | 0.96–2.55 | 0.08 | 1.58 | 0.96–2.60 | 0.07 |
| Chronic inflammatory disease† (yes/no) | 1.47 | 0.94–2.29 | 0.09 | 1.64 | 1.04–2.60 | 0.03 |
| PCT >1 μg/L (vs. PCT <1 μg/L) | 1.30 | 0.98–1.71 | 0.07 | 1.32 | 0.97–1.79 | 0.08 |
| PaO2/FiO2 Q1 (vs. Q2–Q4) | 1.13 | 0.88–1.44 | 0.4 | 0.97 | 0.75–1.26 | 0.8 |
| SPD (≥85th percentile vs. SPD <85th percentile) | 1.73 | 1.35–2.21 | <10–4 | 1.45 | 1.11–1.88 | 0.006 |
| COPD (yes/no) | 1.62 | 1.24–2.12 | 0.0005 | 1.57 | 1.18–2.09 | 0.002 |
| Apache II score (<25 vs. ≥25) | 1.67 | 1.31–2.13 | <10–4 | 1.53 | 1.18–1.99 | 0.001 |
| Gelsolin Q1 (vs. Q2–Q4) | 0.92 | 0.70–1.22 | 0.6 | 1.04 | 0.77–1.39 | 0.8 |
Significant results (P < 0.05) are marked with bold font.
*Acute myocardial infarction, pulmonary embolism, cerebral infarction, mesenteric embolism, and medulla spinalis infarction.
†Rheumatoid arthritis, Sjögren syndrome, fibromyalgia, spondylosis, hepatic cirrhosis, systemic lupus erythematosus, vasculitis, and chronic glomerulonephritis.
COPD indicates chronic obstructive pulmonary disease; PCT, procalcitonin; Q1, lower quartile; Q2–Q4, upper 3 quartiles; SPD, surfactant protein D.