Table 4.

Predictors of “alive and out of ICU at day 14” – Cox regression

	Univariable			Multivariable
Variable	HR	95% CI	P value	HR	95% CI	P value
Age (per year increase)	0.99	0.99–1.00	0.037	0.99	0.99–1.00	0.053
Gender (male vs. female)	1.032	0.85–1.26	0.75	1.01	0.83–1.24	0.90
Severe sepsis/septic shock (vs. milder or no infection)	0.58	0.47–0.72	<10–4	0.72	0.57–0.91	0.006
Surgical origin (yes vs. no)	1.050	0.85–1.30	0.66	1.03	0.82–1.30	0.79
Acute thrombosis* (yes vs. no)	1.24	0.75–2.047	0.40	1.13	0.68–1.89	0.63
Chronic inflammatory disease† (yes vs. no)	0.73	0.45–1.21	0.22	0.84	0.50–1.49	0.49
PCT >1 μg/L (vs. PCT <1 μg/L)	0.56	0.45–0.69	<10–4	0.67	0.53–0.84	0.0008
PaO2/FiO2 Q1 (vs. Q2–Q4)	0.77	0.62–0.96	0.021	0.87	0.69–1.09	0.22
SPD (≥85th percentile vs. SPD <85th percentile)	0.77	0.61–0.98	0.032	0.73	0.56–0.94	0.014
COPD (yes/no)	0.90	0.69–1.17	0.43	0.79	0.60–1.04	0.094
Apache II score (<25 vs. ≥25)	0.64	0.51–0.81	0.0002	0.76	0.60–0.97	0.028
Gelsolin Q1 (vs. Q2–Q4)	0.63	0.50–0.81	0.0002	0.69	0.54–0.89	0.0045

Significant results (P < 0.05) are marked with bold font.

^*Acute myocardial infarction, pulmonary embolism, cerebral infarction, mesenteric embolism, and medulla spinalis infarction.

^†Rheumatoid arthritis, Sjögren syndrome, fibromyalgia, spondylosis, hepatic cirrhosis, systemic lupus erythematosus, vasculitis, and chronic glomerulonephritis.

COPD indicates chronic obstructive pulmonary disease; PCT, procalcitonin; Q1, lower quartile; Q2–Q4, upper 3 quartiles; SPD, surfactant protein D.