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. 2019 Jul 22;25(5):410–417. doi: 10.1097/MCP.0000000000000610

FIGURE 1.

FIGURE 1

Pathobiology of right ventricular failure in pulmonary arterial hypertension. Schematic overview of mechanisms affecting and maintaining right ventricular wall tension and dysfunction in pulmonary arterial hypertension and medical treatments targeting these mechanisms. BAS, balloon artrial septostomy; CO, cardiac output; ECMO, extra corporal membrane oxygenation; ERAs, endothelin receptor antagonists; FAO, fatty acid oxidation; PDE-5, phosphodiesterase type 5; PDK, pyruvaat dehydrogenase kinase; RAAS, renin–angiotensin aldosterone system; rhACE2, recombinant human angiotensin converting enzyme 2; RV, right ventricle; RVAD, right ventricular assist device.