Table 4.

Association of the GRS with Change in Traits at 1 Year

Year 1-Baseline	Sample Size (n)	β Estimate per Allele	SE	P
Weight, kga	2568	0.1234	0.0529	0.020
BMI, kg/m2a	2568	0.0461	0.0190	0.015
Waist circumference, cma	2568	0.0754	0.0593	0.204
FI, μU/mL, ln	2568	0.0130	0.0043	0.002
Fasting glucose, mg/dL, lna	2568	0.0003	0.0009	0.722
ISI, lnb	2506	−0.0136	0.0047	0.004
Systolic blood pressure, mm Hg	2568	−0.0874	0.1134	0.441
Diastolic blood pressure, mm Hg	2568	0.0277	0.0740	0.708
HDL-cholesterol, mg/dL	2559	0.0043	0.0591	0.942
LDL-cholesterol, mg/dL	2559	0.0067	0.2033	0.974
Triglycerides, mg/dL, ln +	2559	0.0047	0.0033	0.154
ALT, U/L, ln+	1857	0.0801	0.1211	0.509
Visceral adipose tissue, cm2, L4-5	618	−0.0006	0.0017	0.721
Subcutaneous adipose tissue, cm2, L4-5	618	0.4760	1.0300	0.644

All measures adjusted for baseline value, age at randomization, sex and self-reported race/ethnicity, waist circumference and treatment group except where indicated.

Abbreviation: FI, fasting insulin.

^aAdjusted for age at randomization, sex, and race/ethnicity

^bln (Year 1 measurement) - ln (Baseline measurement)