Table 3. Genotype distribution of target SNPs in cases and controls.
Gene | SNP | Dominant model |
Recessive model |
||||||||||
Aa+aaa | AAa | Aa+aab | AAb | OR (95%CI) | P | aaa | AA+Aaa | aab | AA+Aab | OR (95%CI) | P | ||
MYOC | rs12076134 | 169 | 331 | 251 | 468 | 0.960 (0.732-1.26) | 0.769 | 19 | 481 | 33 | 686 | 0.858 (0.447-1.649) | 0.647 |
MYOC | rs183532 | 205 | 295 | 318 | 402 | 0.748 (0.575-0.972) | 0.029 | 24 | 476 | 47 | 673 | 0.707 (0.403-1.242) | 0.228 |
MYOC | rs235875 | 261 | 239 | 357 | 363 | 1.114 (0.861-1.441) | 0.412 | 57 | 443 | 57 | 663 | 1.595 (1.04-2.446) | 0.032 |
MYOC | rs235913 | 307 | 193 | 483 | 237 | 0.776 (0.593-1.015) | 0.064 | 82 | 418 | 120 | 600 | 0.987 (0.698-1.397) | 0.942 |
ABCA1 | rs2422493 | 325 | 175 | 488 | 232 | 0.852 (0.649-1.12) | 0.251 | 83 | 417 | 114 | 606 | 1.168 (0.822-1.661) | 0.386 |
ABCA1 | rs2487042 | 238 | 262 | 354 | 366 | 0.858 (0.663-1.11) | 0.243 | 46 | 454 | 58 | 662 | 1.324 (0.831-2.112) | 0.238 |
ABCA1 | rs2472496 | 331 | 169 | 497 | 223 | 0.836 (0.635-1.101) | 0.203 | 94 | 406 | 125 | 595 | 1.221 (0.873-1.71) | 0.244 |
ABCA1 | rs2472493 | 351 | 149 | 524 | 195 | 0.861 (0.647-1.146) | 0.305 | 106 | 394 | 142 | 577 | 1.18 (0.855-1.628) | 0.314 |
ABCA1 | rs2487032 | 344 | 156 | 517 | 202 | 0.795 (0.599-1.055) | 0.112 | 105 | 395 | 143 | 576 | 1.126 (0.816-1.554) | 0.471 |
ABCA1 | rs2472459 | 250 | 250 | 370 | 350 | 0.865 (0.668-1.119) | 0.270 | 54 | 446 | 64 | 656 | 1.401 (0.899-2.183) | 0.137 |
ABCA1 | rs2472519 | 264 | 236 | 385 | 333 | 0.846 (0.653-1.095) | 0.204 | 62 | 438 | 71 | 647 | 1.443 (0.95-2.192) | 0.086 |
SNP: Single nucleotide polymorphisms; OR: Odds ratio; CI: Confidence intervals. aThe genotype counts in cases; bThe genotype counts in controls; a represents the minor allele, A represents the wild allele; Dominant model: Aa+aa compared with AA; Recessive model: aa compared with AA+Aa. P, OR, and CI were calculated with logistic regression model by adjusting for age and gender.