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. 2019 Aug 18;12(8):1250–1261. doi: 10.18240/ijo.2019.08.04

Figure 6. Resveratrol protects against NMDA-induced retinal damage.

Figure 6

A-E: Zebrafish were treated intravitreally with NMDA and by I.M. in resveratrol. A: H&E staining of paraffin sections (4 µm) from retinas treated with I.V. of 100 nL PBS (control), or 0.5 mol/L NMDA, each plus or minus I.M. in 50 mg/L resveratrol. The dark arrows point out the thickness of each layer. B: The thickness of the NFL+GCL from each treatment group; C: The thickness of the retinas from each treatment group; D: The retinal ganglion cell number from each treatment group. Error bars represent standard error of the mean (SEM); n=6 (unpaired t-test, aP<0.05, bP<0.01, and cP<0.0001 compared with control); E: Representative TUNEL staining images of each treatment group as in A. The white arrows point to apoptotic cells. Original magnification is 40×. Scale bar, 50 µm.