Table 2.

Sample size calculations for equivalence in means of duration of severe neutropenia (t test)

Hypothesis to be evaluated: μ r − μ b ≤ d days vs H1: μ r − μ b > d days Assumptions: CI, 97.5%; expected difference in means 0.25 days; randomization 1:1
Power	80%				90%
Non-inferiority limit	− 1 day		− 0.5 days		− 1 day		− 0.5 days
Standard deviation	1.5	2	1.5	2	1.5	2	1.5	2
N per group	24	42	64	113	32	55	86	151