. 2019 Aug 14;9:11804. doi: 10.1038/s41598-019-48399-4

Table 3.

RRs for vulvar/vaginal cancer when family members were diagnosed with any cancer, and RR for cancer when family members were diagnosed with vulvar/vaginal cancer.

Cancer site family member	RR for vulvar/vaginal cancer			RR for cancer
Cancer site family member	Familial cases	RR^b	95% CI^c	Familial cases	RR	95% CI
Upper aerodigestive tract	32	1.03	0.73–1.47	49	1.18	0.89–1.56
Salivary glands	4	1.23	0.46–3.28	5	1.08	0.45–2.61
Esophagus	9	0.80	0.41–1.53	13	0.90	0.52–1.56
Stomach	63	1.23	0.96–1.58	29	0.94	0.65–1.36
Small intestine	5	0.82	0.34–1.98	7	0.81	0.38–1.69
Colorectum	150	0.98	0.83–1.15	175	0.98	0.85–1.14
Anus	7	2.38	1.14–5.01	11	2.13	1.18–3.85
Liver	48	1.34	1.01–1.78	22	0.68	0.45–1.03
Pancreas	35	0.94	0.67–1.31	38	1.04	0.75–1.42
Nose	6	2.68	1.20–5.97	4	1.48	0.56–3.96
Lung	130	1.32	1.10–1.57	151	1.13	0.96–1.32
Breast (female and male)	166	0.96	0.82–1.13	312	0.94	0.84–1.05
Cervix	24	0.99	0.66–1.48	24	0.71	0.48–1.07
Endometrium	48	1.25	0.94–1.66	62	1.16	0.90–1.48
Uterus, unspecified	2	0.47	0.12–1.89	12	1.98	1.12–3.49
Ovary	27	0.88	0.60–1.29	39	0.89	0.65–1.22
Vulvar/vaginal	17	2.72	1.69–4.39
Prostate	191	0.90	0.77–1.04	273	0.84	0.75–0.95
Testis	3	0.70	0.23–2.17	18	0.92	0.58–1.46
Penile	4	1.51	0.56–4.02	6	1.62	0.72–3.61
Kidney	41	1.03	0.76–1.41	48	1.05	0.79–1.40
Urinary bladder	72	1.12	0.89–1.42	94	1.29	1.05–1.58
Melanoma	57	1.24	0.95–1.61	90	0.80	0.65–0.98
Skin	59	0.98	0.76–1.27	62	0.99	0.77–1.27
Eye	2	0.50	0.12–1.99	5	0.82	0.34–1.96
Nervous system	48	1.23	0.93–1.64	72	0.90	0.72–1.14
Thyroid gland	10	0.91	0.49–1.70	14	0.67	0.39–1.13
Endocrine glands	25	1.08	0.73–1.60	37	0.92	0.66–1.27
Bone	4	1.94	0.73–5.17	2	0.36	0.09–1.43
Connective tissue	11	1.27	0.70–2.30	18	1.30	0.82–2.07
Non-Hodgkin lymphoma	38	0.90	0.66–1.25	65	1.02	0.80–1.30
Hodgkin lymphoma	6	0.98	0.44–2.19	11	0.81	0.45–1.46
Myeloma	19	0.95	0.60–1.49	18	0.86	0.54–1.37
Leukemia	39	1.00	0.73–1.37	44	0.77	0.57–1.03
CUP^a	42	0.95	0.70–1.28	32	0.71	0.50–1.00
All (including vulvar/vaginal)	1027	1.05	0.96–1.14	1880	0.95	0.91–1.00

CUP^a = cancer of unknown primary. RR^b = relative risk. 95% CI^c = 95% confidence interval, bold font indicates that the lower limit of 95% CI does not include 1.00.