Table 4.

RRs of second primary cancers (SPCs) in survivors of penile cancer and other cancers.

Cancer site	After penile cancer			After other cancers
	SPCs	RRb	95% CIc	SPCs	RR	95% CI
Upper aerodigestive tract	19	1.12	0.72–1.76	14	0.64	0.38–1.08
Salivary gland	0	—	—	0	—	—
Esophagus	8	1.01	0.51–2.02	1	0.37	0.05–2.60
Stomach	24	0.76	0.52–1.14	10	0.51	0.28–0.95
Small intestine	3	1.10	0.35–3.40	1	0.33	0.05–2.34
Colorectum	70	0.90	0.71–1.13	38	0.35	0.26–0.49
Anus	3	3.97	1.28–12.31	4	2.19	0.82–5.84
Liver	14	0.83	0.49–1.39	2	0.29	0.07–1.18
Pancreas	19	1.08	0.69–1.70	0	—	—
Nose	0	—	—	0	—	—
Lung	69	1.23	0.97–1.56	4	0.18	0.07–0.49
Breast	2	1.96	0.49–7.85	1	0.01	0.001–0.04
Prostate	175	0.85	0.73–0.99	123	0.82	0.69–0.99
Testis	2	2.06	0.52–8.25	6	1.64	0.74–3.65
Penile	26	11.68	7.95–17.18
Kidney	12	0.66	0.37–1.16	3	0.14	0.05–0.45
Urinary bladder	47	1.03	0.78–1.37	28	0.57	0.39–0.82
Melanoma	12	0.72	0.41–1.28	19	0.51	0.32–0.79
Skin	46	1.11	0.83–1.49	36	0.70	0.21–0.98
Eye	0	—	—	1	0.32	0.04–2.24
Nervous system	9	0.88	0.46–1.69	4	0.20	0.08–0.54
Thyroid gland	0	—	—	3	0.32	0.10–0.99
Endocrine glands	3	0.71	0.23–2.21	3	0.14	0.05–0.43
Bone	1	1.77	0.25–12.59	1	0.71	0.10–5.04
Connective tissue	5	1.44	0.60–3.46	4	0.71	0.27–1.88
Non-Hodgkin lymphoma	14	0.75	0.44–1.26	13	0.61	0.36–1.06
Hodgkin lymphoma	2	1.07	0.27–4.26	2	0.62	0.16–2.49
Myeloma	1	0.11	0.01–0.75	2	0.26	0.06–1.03
Leukemia	12	0.65	0.37–1.14	5	0.27	0.11–0.65
CUPa	12	0.67	0.38–1.18	8	0.85	0.43–1.71
All (excluding penile)	584	1.08	1.00–1.18	336	0.42	0.38–0.47

CUP^a = cancer of unknown primary. RR^b = relative risk. 95% CI^c = 95% confidence interval, bold font indicates that the lower limit of 95% CI does not include 1.00.